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Intrinsic toxicity

What are intrinsic toxicity factors?

The intrinsic toxicity of nanoparticles depends on the physical and chemical parameters:

Physico-chemical parameters

These parameters determined:

  • the reactivity to biological environment,
  • the overcoming passage of biological barriers: alveolar capillary, blood-brain,…
  • interaction with the biological environment (DNA, proteins,…).

Nanoparticle interaction with cells: intracellular targets and nanotoxicological mechanisms [A. Elsaesser et al., Advanced Drug Delivery Reviews 64 (2012) 129-137].